U-Share-funded collaboration projects

So far, three projects have been granted funding in U-Share’s call for applications for collaboration projects. The projects have a PI at either SLU or UU, and a postdoctoral researcher with a PhD from the other university.

A solution for spinal injury: A biomaterial that stabilises injured vertebra and stimulates new bone growth

Odd Höglund and Michael Pujari-Palmer
The goal of this project is to be able to fuse vertebras using only a biomaterial, without the need for fixation or invasive metal implants. The researchers will evaluate two new biomaterials, an osteostimulatory cement and a bone adhesive, that can improve healing of bone tissue and achieve fusion based on the biological and regenerative properties of the material. The findings could be used to develop treatment strategies in cases of spinal weakness or instability, caused by for instance a fracture or arthritis, when a portion of the vertebral disc is removed or replaced and the adjoining vertebral surfaces need to be fused to stabilise the spine.
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AI tools to predict risk of common diseases using genetic data

Åsa Johansson and Hadrien Gourlé
In this project the researchers aim to develop a novel Artificial Intelligence (AI) tool than can enable the identification of individuals with high risk of developing a disease. They will combine AI tools with large-scale sequencing data from a cohort with more than half a million participants. The focus will be on a subset of common diseases, such as osteoporosis and myocardial infarction, where the models can be verified in a clinical setting and for which good preventive treatments are available. With this approach, the researchers hope to develop a new AI tool for disease prediction that goes beyond the ones that are state-of the art today.
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Targeting mast cells and carboxypeptidase A in asthma

Sara Wernersson and Srinivas Akula
The researchers that have joined forces in this project are studying a potential target for new treatments and diagnosis methods for asthma in humans and horses. They are focusing on mast cells, which are involved in allergic reactions, and a protein in these cells called carboxypeptidase A3, or CPA3 in short. To perform functional analyses of CPA3 the researchers need to obtain enough quantities of the pure protein and they are therefore producing recombinant proteins of both human, mouse and horse versions of CPA3. The function of the recombinant proteins is studied in lung tissues related to asthma. In another part of the project, they explore the role of mast cells in asthma in horses.
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Last modified: 2021-09-16