Recent joint publications
Carriage of antibiotic resistant bacteria between animals and humans
The study found that in rural Cambodia, E. coli and K. pneumoniae bacteria that carry antibiotic resistance genes are often spread via faeces, especially in women and young children. Household practices that involve contact with animal manure and slaughter products increase the risk for humans being infected with such bacteria.
The study was performed by Clara Atterby and Josef Järhult, Dept. of Medical Sciences, UU, Kristina Osbjer, Elisabeth Rajala and Ulf Magnusson, Dept. of Clinical Sciences, SLU, researchers from the National Veterinary Institute, Linnaeus University and Kalmar County Hospital, and researchers in Cambodia and Switzerland.
Paper in the journal Zoonoses and Public Health: Carriage of carbapenemase‐ and extended‐spectrum cephalosporinase‐producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of blaOXA‐48 in humans.
Interference from canine anti‐mouse antibodies in hormone immunoassays
Immunoassays are standard methods for the diagnosis of many medical conditions but there are some limitations. In this study the researchers found that anti-mouse antibodies in dogs are a source of erroneous results in the Anti-Müllerian hormone assay. They conclude that veterinary clinicians and technicians need to be aware of the risk of immunoassay interference from endogenous antibodies.
The research team behind the study was Daniel Bergman, Helene Hansson‐Hamlin and Bodil Ström Holst, Dept. of Clinical Sciences, SLU, together with Anders Larsson, Dept. of Medical Sciences, UU.
Paper in the journal Veterinary Clinical Pathology: Investigation of interference from canine anti-mouse antibodies in hormone immunoassays.
Diagnostic value of different markers for kidney disease in dogs
There is a need for improved methods to detect decreased glomerular filtration rate (GFR) in dogs, which can function as an indicator of kidney disease. In the study the overall diagnostic performance of two markers for GFR was found to be the same, and one marker was inferior to the others. Using two or three markers in combination may provide additional value for diagnosis of decreased GFR.
The study was performed at SLU by Lena Pelander, Jens Häggström and Ingrid Ljungvall, Dept of Clinical Sciences, in collaboration with Anders Larsson, Dept of Medical Sciences, UU, and researchers in Norway and the UK.
Paper in Journal of Veterinary Internal Medicine: Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs
The antihistamine cetirizine can prevent symptoms of allergic responses in dogs
The effect of oral administration of the antihistamine cetirizine to dogs was investigated and a dose of 2–4 mg/kg was found to provide an antihistamine response without any apparent adverse effects. This indicates that cetirizine may be an option to treat histamine-mediated inflammation in the dog.
Carl Ekstrand, Carina Ingvast‑Larsson and Lena Olsén at the Department of Biomedicine and Veterinary Public Health, and Department of Clinical Sciences, SLU, conducted the study together with Ulf Bondesson and Mikael Hedeland, Department of Medicinal Chemistry, UU.
Paper in Acta Veterinaria Scandinavica: Cetirizine per os: exposure and antihistamine effect in the dog
Kinetic study of the response to experimentally induced mastitis in cows
An experimental procedure to induce mastitis in cow udders resulted in clinical signs of mastitis and an accumulation of inflammatory mediators and metabolites both in blood plasma and milk. The changes in the milk occurred with a delay as compared to the clinical signs and the effect on the plasma.
The study was led by Gunnar Pejler who is affiliated with Dept. Anatomy, Physiology and Biochemistry at SLU and Dept. Medical Biochemistry and Microbiology, UU. Additional authors at SLU were Carl-Fredrik Johnzon and Ida Waern, Dept. Anatomy, Physiology and Biochemistry; Josef Dahlberg, Dept. Animal Nutrition and Management; Ali A Moazzami, Dept. Molecular Sciences; Karin Östensson, Dept. Clinical Sciences. From UU, Ann-Marie Gustafsson, Dept. Medical Biochemistry and Microbiology, was also part of the research team.
Paper in Frontiers in Immunlogy: The effect of lipopolysaccharide-induced experimental bovine mastitis on clinical parameters, inflammatory markers, and the metabolome: a kinetic approach
Prevalence of interfering antibodies in dogs and cats
In the study, interference – most likely caused by interfering antibodies – was detected in immunoassays of patient samples from dogs and cats. The interference could be neutralized using an immunoassay based on nonmammalian reagents. Eliminating interference in immunoassays is important to avoid misdiagnosis of animals in the clinic.
The study was performed by SLU researchers Daniel Bergman, Helene Hansson-Hamlin, Anna Svensson and Bodil Ström Holst, Dept of Clinical Sciences, in collaboration with Anders Larsson, Department of Medical Sciences, Uppsala University.
Paper in Veterinary Clinical Pathology: Prevalence of interfering antibodies in dogs and cats evaluated using a species-independent assay