Recent joint publications
Potential health risk with AA amyloid in cow meat
The disease amyloidosis is caused by the accumulation of AA amyloid fibrils. Researchers have now detected AA amyloid in meat from Swedish and Italian cows. They have also performed experiments where small amounts of AA amyloid from cows could induce the formation of an amyloid called A-beta which is associated with Alzheimer’s disease. Further studies are needed to determine if eating cow meat is a health risk.
The study was performed by Anna Rising, Dept of Anatomy, Physiology and Biochemistry, SLU and Karolinska Institutet, Gunilla T. Westermark, Dept of Medical Cell Biology, UU, and Per Westermark, Dept of Immunology, Genetics and Pathology, UU, in collaboration with colleagues at Karolinska Institutet and in Italy.
Paper in Scientific Reports: AA amyloid in human food chain is a possible biohazard
Substances identified that may affect fertility in women
Involuntary childlessness affects millions of people worldwide. The method used in this study included analyses of follicular fluid and serum in women undergoing in vitro fertilisation. The researchers could identify substances that were associated both with lower and higher embryo quality and the method was found to be applicable for discovering both anthropogenic and endogenous substances with a potential role for fertility in women.
Authors of the paper are Ida Hallberg, Ylva Sjunnesson and Sara Persson, Dept of Clinical Sciences, SLU, Matts Olovsson and Jan Holte, Dept of Women’s and Children’s Health, UU, together with researchers from Stockholm University, Karolinska Institutet and Karolinska University Hospital.
Paper in Environmental Science – Processes & Impacts: Suspect and non-target screening of ovarian follicular fluid and serum – identification of anthropogenic chemicals and investigation of their association to fertility
The ABCC4 gene associated with pyometra in golden retrievers
The disease pyometra in dogs is an inflammation and bacterial infection of the uterus. Since the disease is more common in some dog breeds it is likely that genetic risk factors influence disease pathogenesis. The present study identified genetic variants of the gene ABCC4 that were associated with pyometra in golden retrievers. This suggests that the gene has a potential role in disease development.
The study was performed by UU researchers Maja Arendt, Katarina Tengvall, Jennifer R. S. Meadows, Åsa Karlsson and Kerstin Lindblad‑Toh, Department of Medical Biochemistry and Microbiology, Tove Fall, Department of Medical Sciences, and Marcin Kierczak, Department of Cell and Molecular Biology, and SLU researchers Aime Ambrosen, Anne‑Sofie Lagerstedt and Ragnvi Hagman, Department of Clinical Sciences, and Tomas Bergström and Göran Andersson, Department of Animal Breeding and Genetics.
Paper in Scientific Reports: The ABCC4 gene is associated with pyometra in golden retriever dogs
Immunotherapy could be beneficial for dogs with malignant melanoma
Malignant melanoma in dogs is an excellent model for comparisons with human malignant melanoma. In this long-term follow-up, 32 dogs with malignant melanoma were given gene therapy with an adenovirus containing the immunostimulatory gene CD40L. The average survival was 285 days and the treatment was found to be safe, suggesting that it could be beneficial for dogs. Further research is ongoing to determine if the therapy can be used also in humans.
The study was a collaboration between Sara Sällström, University Animal Hospital, SLU; Henrik Rönnberg Dept of Clinical Sciences, SLU; Arian Sadeghi, Emma Eriksson, Olle Korsgren, Angelica Loskog and Thomas H. Tötterman, Dept of Immunology, Genetics and Pathology, UU, and researchers at the Swedish National Veterinary Institute, University of Helsinki and Helsinki University Hospital.
Web news SLU (in Swedish)
Paper in Frontiers in Veterinary Science: Adenoviral CD40 Ligand immunotherapy in 32 canine malignant melanomas – Long-term follow-up
New insights regarding pigs as diabetes models
Type 2 diabetes can be treated by inhibiting the glucagon-like peptide (GLP-1) receptor but the mode of action of GLP-1 is not fully understood. The researchers in this study examined the distribution of GLP-1 receptors in pig pancreas and intestines and found both similarities and differences between pigs and humans in GLP-1 regulation and secretion. This should be considered when pigs are used as animal models in diabetes research.
The study was performed as a collaboration between SLU researchers Elin Manell, Anna Svensson, Patricia Hedenqvist and Marianne Jensen Waern, Dept of Clinical Sciences, and UU researchers Emmi Puuvuori, Gry Hulsart-Billström and Olof Eriksson, Dept of Medicinal Chemistry, together with Jens Juul Holst, University of Copenhagen.
Paper in BMJ Open Diabetes Research & Care: Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Standard treatment of juvenile idiopathic arthritis does not alter fecal microbiota
For children with juvenile idiopathic arthritis (JIA) the standard treatment is usually methotrexate (MTX) followed by etanercept (ETN). This study on the fecal microbiota of children with JIA revealed that treatment with MTX or ETN resulted in minor differences in the microbiota composition. However, no significant or consistent changes were found which suggests that the observed changes were not related to the therapeutic effects of the drugs.
The study was performed by Anders Öman and Lillemor Berntson, Dept of Women’s and Children’s Health, UU, in collaboration with Johan Dicksved, Dept of Animal Nutrition and Management, SLU, and Lars Engstrand, Karolinska Institutet,
Paper in Pediatric Rheumatology: Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept
3D printed implant can guide bone regeneration
Long bone fractures are common and can be difficult to treat. If a bone defect is large, it is sometimes not possible for the body to fill the bone void. This study evaluated the use of a calcium phosphate cement (CPC) implant, manufactured through indirect 3D printing, on long bone defects in rabbits. The CPC material was found to be associated with new bone formation and the researchers conclude that an indirectly 3D printed implant has the potential to guide bone regeneration in long bone defects.
Shared first authors of the study were UU researchers Torbjörn Mellgren, Dept. of Engineering Sciences, and Amela Trbakovic, Dept. of Surgical Sciences. Last author was Patricia Hedenqvist, Dept of Clinical Sciences, SLU. Others who contributed to the study were Andreas Thor, Surgical Sciences, UU, Cecilia Ley and Caroline Öhman-Mägi, Engineering Sciences, UU, Stina Ekman, Biomedical Sciences and Veterinary Public Health, SLU, Marianne Jensen-Waern, Clinical Sciences, SLU, and Petra Hammarström Johansson, Institution for odontology, University of Gothenburg.
Paper in Biomedical Materials: Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect