Recent joint publications
Evaluation of methods to assess insulin sensitivity in horses
The disease laminitis in horses can be associated with insulin resistance (IR) and it is important to identify horses and ponies at risk. Proxies are calculations that can be used to predict insulin sensitivity but they have not been validated in horses with IR. The study demonstrated that fasting insulin (FI) and all investigated proxies provided repeatable estimates of horses’ insulin sensitivity but there was no advantage of using proxies instead of FI to estimate IR in the horse.
The study was performed by Sanna Lindåse, Katarina Nostell and Johan Bröjer, Dept of Clinical Sciences, SLU, in collaboration with UU researchers Peter Bergsten and Anders Forslund, Dept of Women’s and Children’s Health.
Paper in BMC Veterinary Research: Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses.
New map of the dog genome aids disease genetics
Comparing the human and dog genomes can provide valuable information about disease causes. In the current study the researchers used new sequencing technolgoy to map the dog genome in more detail than was previously available. This makes it possible to identify genetic variation in areas that have been difficult to sequence and improves the possibilities to compare genetic diseases in dogs and humans.
Chao Wang, Ola Wallerman, Maja-Louise Arendt, Elisabeth Sundström, Åsa Karlsson, Jessika Nordin, Suvi Mäkeläinen, Gerli Rosengren Pielberg, Jennifer R. S. Meadows and Kerstin Lindblad-Toh, Dept. of Medical Biochemistry and Microbiology, UU, conducted the study together with Jeanette Hanson, Sara Saellström, Henrik Rönnberg, Ingrid Ljungvall, Jens Häggström and Åke Hedhammar, Dept of Clinical Sciences, SLU, and Åsa Ohlsson and Tomas F. Bergström, Dept. of Animal Breeding and Genetics, SLU.
Web news, Uppsala University (in Swedish)
Paper in Communications Biology: A novel canine reference genome resolves genomic architecture and uncovers transcript complexity
The shared risk of diabetes between dog and cat owners and their pets
In a register based, longitudinal cohort study the researchers found that owners of a dog with diabetes were more likely to develop type 2 diabetes than owners of a dog without diabetes. In contrast, no association was found between type 2 diabetes in cat owners and diabetes in their cats. Suggested reasons for the association between dogs and their owners include that they share health behaviors, microbiota and environmental factors.
The study was performed by the UU researchers Rachel Ann Delicano, Ulf Hammar, Tove Fall and Beatrice Kennedy, Dept. Medical Sciences, and Liisa Byberg, Dept Surgical Sciences, in collaboration with Agneta Egenvall, Dept. Clinical Sciences, SLU, and researchers at Karolinska Institutet and University of Liverpool.
Press release Uppsala University (in Swedish)
Paper in the journal BMJ: The shared risk of diabetes between dog and cat owners and their pets: register based cohort study
Pre‑existing autoantibodies can affect the development of canine immunotherapy
Therapeutic antibodies are developed to treat human diseases but only a few veterinary antibodies have so far been approved, mainly due to a lack of information about the canine immune system. This investigation of anti-IgG antibodies in dogs found a widespread occurrence of anti-Fab and anti-F(ab′)2-autoantibodies. Their presence needs to be considered in the development canine immunotherapy as they affect drug safety and efficacy.
The study was performed by SLU researchers Daniel Bergman, Camilla Bäckström, Helene Hansson‑Hamlin and Bodil Ström Holst, Dept of Clinical Sciences, in collaboration with Anders Larsson, Department of Medical Sciences, Uppsala University.
Paper in the journal Scientific Reports: Pre‑existing canine anti‑IgG antibodies: implications for immunotherapy, immunogenicity testing and immunoassay analysis
Owner-perceived pain assessment in dogs with osteoarthritis
To manage pain caused by osteoarthritis in dogs it is important that the owners can recognise, assess and report their dogs’ pain in a subjective way. In this study, the researchers found that owner-reported ratings of pain interference were not associated with medication or with consulting an animal physiotherapist. The lack of response bias indicates that a pain interference score may be used as a clinical outcome measure of chronic pain and pain-related disability in dogs with osteoarthritis.
The study was performed by Ann Essner, Lena Zetterberg and Karin Hellström, Dept. of Neuroscience, UU, and Pia Gustås, Dept. of Clinical Sciences, SLU, together with researchers at the University of Gävle and Umeå University.
Paper in the journal Topics in Companion Animal Medicine: Investigating the Probability of Response Bias in Owner-Perceived Pain Assessment in Dogs With Osteoarthritis
Genetic variant associated with protection against hypothyroidism in dogs
Whole-genome genotyping was used to identify a genetic deletion associated with a decreased risk for Giant Schnauzers to develop hypothyroidism. The deletion was located between two predicted Interferon alpha genes but the researchers could not assign any specific function to the identified genetic variant. However, interferons have previously been associated with human hypothyroidism and the findings suggest that the dog would be a suitable animal model for the human disease. The results might also contribute to the development of improved breeding strategies for dogs.
Matteo Bianchi, Nima Rafati, Åsa Karlsson, Eva Murén, Carl-Johan Rubin, Kerstin Lindblad-Toh and Gerli Rosengren Pielberg, Dept. of Medical Biochemistry and Microbiology, UU, conducted the study together with Katarina Sundberg and Göran Andersson, Dept. of Animal Breeding and Genetics, SLU, Åke Hedhammar, Dept of Clinical Sciences, SLU and Olle Kämpe, Karolinska Institutet.
Paper in the journal BMC Genomics: Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.