Recent joint publications
Dog ownership associated with better outcome after a major cardiovascular event
This register-based study shows that owning a dog is associated with increased survival after acute myocardial infarction or ischemic stroke. The effect was found to be strongest in single households. The results were adjusted for variabilities such as socioeconomic factors and co-morbidity but as other potential differences between dog owners and non-owners were not included in the study the authors could not conclude on any causal effect.
The study was led by Tove Fall and her team at the Dept. Medical Sciences, UU, in collaboration with Liisa Byberg, Dept Surgical Sciences, UU, and Agneta Egenvall, Dept. Clinical Sciences, SLU.
Press release from Uppsala University (in Swedish)
Paper in the journal Circulation: Cardiovascular Quality and Outcomes: Dog Ownership and Survival After a Major Cardiovascular Event – A Register-Based Prospective Study.
Carriage of antibiotic resistant bacteria between animals and humans
The study found that in rural Cambodia, E. coli and K. pneumoniae bacteria that carry antibiotic resistance genes are often spread via faeces, especially in women and young children. Household practices that involve contact with animal manure and slaughter products increase the risk for humans being infected with such bacteria.
The study was performed by Clara Atterby and Josef Järhult, Dept. of Medical Sciences, UU, Kristina Osbjer, Elisabeth Rajala and Ulf Magnusson, Dept. of Clinical Sciences, SLU, researchers from the National Veterinary Institute, Linnaeus University and Kalmar County Hospital, and researchers in Cambodia and Switzerland.
Paper in the journal Zoonoses and Public Health: Carriage of carbapenemase‐ and extended‐spectrum cephalosporinase‐producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of blaOXA‐48 in humans.
Interference from canine anti‐mouse antibodies in hormone immunoassays
Immunoassays are standard methods for the diagnosis of many medical conditions but there are some limitations. In this study the researchers found that anti-mouse antibodies in dogs are a source of erroneous results in the Anti-Müllerian hormone assay. They conclude that veterinary clinicians and technicians need to be aware of the risk of immunoassay interference from endogenous antibodies.
The research team behind the study was Daniel Bergman, Helene Hansson‐Hamlin and Bodil Ström Holst, Dept. of Clinical Sciences, SLU, together with Anders Larsson, Dept. of Medical Sciences, UU.
Paper in the journal Veterinary Clinical Pathology: Investigation of interference from canine anti-mouse antibodies in hormone immunoassays.
Diagnostic value of different markers for kidney disease in dogs
There is a need for improved methods to detect decreased glomerular filtration rate (GFR) in dogs, which can function as an indicator of kidney disease. In the study the overall diagnostic performance of two markers for GFR was found to be the same, and one marker was inferior to the others. Using two or three markers in combination may provide additional value for diagnosis of decreased GFR.
The study was performed at SLU by Lena Pelander, Jens Häggström and Ingrid Ljungvall, Dept of Clinical Sciences, in collaboration with Anders Larsson, Dept of Medical Sciences, UU, and researchers in Norway and the UK.
Paper in Journal of Veterinary Internal Medicine: Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs
The antihistamine cetirizine can prevent symptoms of allergic responses in dogs
The effect of oral administration of the antihistamine cetirizine to dogs was investigated and a dose of 2–4 mg/kg was found to provide an antihistamine response without any apparent adverse effects. This indicates that cetirizine may be an option to treat histamine-mediated inflammation in the dog.
Carl Ekstrand, Carina Ingvast‑Larsson and Lena Olsén at the Department of Biomedicine and Veterinary Public Health, and Department of Clinical Sciences, SLU, conducted the study together with Ulf Bondesson and Mikael Hedeland, Department of Medicinal Chemistry, UU.
Paper in Acta Veterinaria Scandinavica: Cetirizine per os: exposure and antihistamine effect in the dog