Recent joint publications

Genetic variant associated with protection against hypothyroidism in dogs

June 2020
Whole-genome genotyping was used to identify a genetic deletion associated with a decreased risk for Giant Schnauzers to develop hypothyroidism. The deletion was located between two predicted Interferon alpha genes but the researchers could not assign any specific function to the identified genetic variant. However, interferons have previously been associated with human hypothyroidism and the findings suggest that the dog would be a suitable animal model for the human disease. The results might also contribute to the development of improved breeding strategies for dogs.
Matteo Bianchi, Nima Rafati, Åsa Karlsson, Eva Murén, Carl-Johan Rubin, Kerstin Lindblad-Toh and Gerli Rosengren Pielberg, Dept. of Medical Biochemistry and Microbiology, UU, conducted the study together with Katarina Sundberg and Göran Andersson, Dept. of Animal Breeding and Genetics, SLU, Åke Hedhammar, Dept of Clinical Sciences, SLU and Olle Kämpe, Karolinska Institutet.

More information:
Paper in the journal BMC Genomics: Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.

Dog ownership associated with better outcome after a major cardiovascular event

October 2019
This register-based study shows that owning a dog is associated with increased survival after acute myocardial infarction or ischemic stroke. The effect was found to be strongest in single households. The results were adjusted for variabilities such as socioeconomic factors and co-morbidity but as other potential differences between dog owners and non-owners were not included in the study the authors could not conclude on any causal effect.
The study was led by Tove Fall and her team at the Dept. Medical Sciences, UU, in collaboration with Liisa Byberg, Dept Surgical Sciences, UU, and Agneta Egenvall, Dept. Clinical Sciences, SLU.

More information:
Press release from Uppsala University (in Swedish)
Paper in the journal Circulation: Cardiovascular Quality and Outcomes: Dog Ownership and Survival After a Major Cardiovascular Event – A Register-Based Prospective Study.

Carriage of antibiotic resistant bacteria between animals and humans

July 2019
The study found that in rural Cambodia, E. coli and K. pneumoniae bacteria that carry antibiotic resistance genes are often spread via faeces, especially in women and young children. Household practices that involve contact with animal manure and slaughter products increase the risk for humans being infected with such bacteria.
The study was performed by Clara Atterby and Josef Järhult, Dept. of Medical Sciences, UU, Kristina Osbjer, Elisabeth Rajala and Ulf Magnusson, Dept. of Clinical Sciences, SLU, researchers from the National Veterinary Institute, Linnaeus University and Kalmar County Hospital, and researchers in Cambodia and Switzerland.

More information:
Paper in the journal Zoonoses and Public Health: Carriage of carbapenemase‐ and extended‐spectrum cephalosporinase‐producing Escherichia coli and Klebsiella pneumoniae in humans and livestock in rural Cambodia; gender and age differences and detection of blaOXA‐48 in humans

Interference from canine anti‐mouse antibodies in hormone immunoassays

July 2019
Immunoassays are standard methods for the diagnosis of many medical conditions but there are some limitations. In this study the researchers found that anti-mouse antibodies in dogs are a source of erroneous results in the Anti-Müllerian hormone assay. They conclude that veterinary clinicians and technicians need to be aware of the risk of immunoassay interference from endogenous antibodies.
The research team behind the study was Daniel Bergman, Helene Hansson‐Hamlin and Bodil Ström Holst, Dept. of Clinical Sciences, SLU, together with Anders Larsson, Dept. of Medical Sciences, UU.

More information:
Paper in the journal Veterinary Clinical Pathology: Investigation of interference from canine anti-mouse antibodies in hormone immunoassays.

Diagnostic value of different markers for kidney disease in dogs

Feb 2019
There is a need for improved methods to detect decreased glomerular filtration rate (GFR) in dogs, which can function as an indicator of kidney disease. In the study the overall diagnostic performance of two markers for GFR was found to be the same, and one marker was inferior to the others. Using two or three markers in combination may provide additional value for diagnosis of decreased GFR.
The study was performed at SLU by Lena Pelander, Jens Häggström and Ingrid Ljungvall, Dept of Clinical Sciences, in collaboration with Anders Larsson, Dept of Medical Sciences, UU, and researchers in Norway and the UK.

More information:
Paper in Journal of Veterinary Internal Medicine: Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dog