Recent joint publications
New insights regarding pigs as diabetes models
Type 2 diabetes can be treated by inhibiting the glucagon-like peptide (GLP-1) receptor but the mode of action of GLP-1 is not fully understood. The researchers in this study examined the distribution of GLP-1 receptors in pig pancreas and intestines and found both similarities and differences between pigs and humans in GLP-1 regulation and secretion. This should be considered when pigs are used as animal models in diabetes research.
The study was performed as a collaboration between SLU researchers Elin Manell, Anna Svensson, Patricia Hedenqvist and Marianne Jensen Waern, Dept of Clinical Sciences, and UU researchers Emmi Puuvuori, Gry Hulsart-Billström and Olof Eriksson, Dept of Medicinal Chemistry, together with Jens Juul Holst, University of Copenhagen.
Paper in BMJ Open Diabetes Research & Care: Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Standard treatment of juvenile idiopathic arthritis does not alter fecal microbiota
For children with juvenile idiopathic arthritis (JIA) the standard treatment is usually methotrexate (MTX) followed by etanercept (ETN). This study on the fecal microbiota of children with JIA revealed that treatment with MTX or ETN resulted in minor differences in the microbiota composition. However, no significant or consistent changes were found which suggests that the observed changes were not related to the therapeutic effects of the drugs.
The study was performed by Anders Öman and Lillemor Berntson, Dept of Women’s and Children’s Health, UU, in collaboration with Johan Dicksved, Dept of Animal Nutrition and Management, SLU, and Lars Engstrand, Karolinska Institutet,
Paper in Pediatric Rheumatology: Fecal microbiota in children with juvenile idiopathic arthritis treated with methotrexate or etanercept
3D printed implant can guide bone regeneration
Long bone fractures are common and can be difficult to treat. If a bone defect is large, it is sometimes not possible for the body to fill the bone void. This study evaluated the use of a calcium phosphate cement (CPC) implant, manufactured through indirect 3D printing, on long bone defects in rabbits. The CPC material was found to be associated with new bone formation and the researchers conclude that an indirectly 3D printed implant has the potential to guide bone regeneration in long bone defects.
Shared first authors of the study were UU researchers Torbjörn Mellgren, Dept. of Engineering Sciences, and Amela Trbakovic, Dept. of Surgical Sciences. Last author was Patricia Hedenqvist, Dept of Clinical Sciences, SLU. Others who contributed to the study were Andreas Thor, Surgical Sciences, UU, Cecilia Ley and Caroline Öhman-Mägi, Engineering Sciences, UU, Stina Ekman, Biomedical Sciences and Veterinary Public Health, SLU, Marianne Jensen-Waern, Clinical Sciences, SLU, and Petra Hammarström Johansson, Institution for odontology, University of Gothenburg.
Paper in Biomedical Materials: Guided bone tissue regeneration using a hollow calcium phosphate based implant in a critical size rabbit radius defect
Evaluation of methods to assess insulin sensitivity in horses
The disease laminitis in horses can be associated with insulin resistance (IR) and it is important to identify horses and ponies at risk. Proxies are calculations that can be used to predict insulin sensitivity but they have not been validated in horses with IR. The study demonstrated that fasting insulin (FI) and all investigated proxies provided repeatable estimates of horses’ insulin sensitivity but there was no advantage of using proxies instead of FI to estimate IR in the horse.
The study was performed by Sanna Lindåse, Katarina Nostell and Johan Bröjer, Dept of Clinical Sciences, SLU, in collaboration with UU researchers Peter Bergsten and Anders Forslund, Dept of Women’s and Children’s Health.
Paper in BMC Veterinary Research: Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses.
New map of the dog genome aids disease genetics
Comparing the human and dog genomes can provide valuable information about disease causes. In the current study the researchers used new sequencing technolgoy to map the dog genome in more detail than was previously available. This makes it possible to identify genetic variation in areas that have been difficult to sequence and improves the possibilities to compare genetic diseases in dogs and humans.
Chao Wang, Ola Wallerman, Maja-Louise Arendt, Elisabeth Sundström, Åsa Karlsson, Jessika Nordin, Suvi Mäkeläinen, Gerli Rosengren Pielberg, Jennifer R. S. Meadows and Kerstin Lindblad-Toh, Dept. of Medical Biochemistry and Microbiology, UU, conducted the study together with Jeanette Hanson, Sara Saellström, Henrik Rönnberg, Ingrid Ljungvall, Jens Häggström and Åke Hedhammar, Dept of Clinical Sciences, SLU, and Åsa Ohlsson and Tomas F. Bergström, Dept. of Animal Breeding and Genetics, SLU.
Web news, Uppsala University (in Swedish)
Paper in Communications Biology: A novel canine reference genome resolves genomic architecture and uncovers transcript complexity
The shared risk of diabetes between dog and cat owners and their pets
In a register based, longitudinal cohort study the researchers found that owners of a dog with diabetes were more likely to develop type 2 diabetes than owners of a dog without diabetes. In contrast, no association was found between type 2 diabetes in cat owners and diabetes in their cats. Suggested reasons for the association between dogs and their owners include that they share health behaviors, microbiota and environmental factors.
The study was performed by the UU researchers Rachel Ann Delicano, Ulf Hammar, Tove Fall and Beatrice Kennedy, Dept. Medical Sciences, and Liisa Byberg, Dept Surgical Sciences, in collaboration with Agneta Egenvall, Dept. Clinical Sciences, SLU, and researchers at Karolinska Institutet and University of Liverpool.
Press release Uppsala University (in Swedish)
Paper in the journal BMJ: The shared risk of diabetes between dog and cat owners and their pets: register based cohort study
Pre‑existing autoantibodies can affect the development of canine immunotherapy
Therapeutic antibodies are developed to treat human diseases but only a few veterinary antibodies have so far been approved, mainly due to a lack of information about the canine immune system. This investigation of anti-IgG antibodies in dogs found a widespread occurrence of anti-Fab and anti-F(ab′)2-autoantibodies. Their presence needs to be considered in the development canine immunotherapy as they affect drug safety and efficacy.
The study was performed by SLU researchers Daniel Bergman, Camilla Bäckström, Helene Hansson‑Hamlin and Bodil Ström Holst, Dept of Clinical Sciences, in collaboration with Anders Larsson, Department of Medical Sciences, Uppsala University.
Paper in the journal Scientific Reports: Pre‑existing canine anti‑IgG antibodies: implications for immunotherapy, immunogenicity testing and immunoassay analysis