U-Share-funded collaboration projects

Two projects have recently been granted funding in U-Share’s call for applications for collaboration projects. The projects have a PI at either SLU or UU, and a postdoctoral researcher with a PhD from the other university.


Targeting mast cells and carboxypeptidase A in asthma

Sara Wernersson and Srinivas Akula
Asthma is a chronic disease in both people and horses, leading to a reduced health and quality of life/welfare. Mast cells are white blood cells that are thought of as being the main cause of asthma symptoms and recent clinical findings have demonstrated a link between asthma and one of the mast cell-restricted proteases, carboxypeptidase A3 (CPA3).

The aim of this project is to identify the mechanisms by which CPA3 contributes to asthma pathology and to explore the role of mast cells in equine asthma. For instance, the researchers will analyse the transcriptome of mast cells from horses’ lungs and perform functional studies of mast cell CPA3. The findings of the study can lead to future development of new and improved diagnostic and therapeutic strategies in human and equine asthma based on targeting CPA3.
 

Antimicrobial resistant bacteria linking animal and human health: determination of the risks along the pork value chain in Vietnam

Johanna Lindahl and Gunilla Ström Hallenberg
Antimicrobial resistance (AMR) in pathogens is believed to be one of the biggest threats to human health in the future. One major contributor to AMR globally is the extensive, and often unnecessary, use of antibiotics in animal production. From animals, AMR can reach humans through food consumption, and one important step in mitigating this is to understand the presence and risks of AMR along the food value chains in developing countries.

This project focuses on AMR in the pork value chain in Vietnam, with the aim to provide novel data on the occurrence and transmission of antimicrobial resistant Salmonella subspecies and Escherichia coli. The researchers will determine the antimicrobial resistance patterns of the bacteria in different steps along the pork value chain and investigate how the bacteria are transmitted through the value chain. They will also create a framework and a qualitative risk assessment for human health from the value chains.