Recent joint publications
Diagnostic value of different markers for kidney disease in dogs
There is a need for improved methods to detect decreased glomerular filtration rate (GFR) in dogs, which can function as an indicator of kidney disease. In the study the overall diagnostic performance of two markers for GFR was found to be the same, and one marker was inferior to the others. Using two or three markers in combination may provide additional value for diagnosis of decreased GFR.
The study was performed at SLU by Lena Pelander, Jens Häggström and Ingrid Ljungvall, Dept of Clinical Sciences, in collaboration with Anders Larsson, Dept of Medical Sciences, UU, and researchers in Norway and the UK.
Paper in Journal of Veterinary Internal Medicine: Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs
The antihistamine cetirizine can prevent symptoms of allergic responses in dogs
The effect of oral administration of the antihistamine cetirizine to dogs was investigated and a dose of 2–4 mg/kg was found to provide an antihistamine response without any apparent adverse effects. This indicates that cetirizine may be an option to treat histamine-mediated inflammation in the dog.
Carl Ekstrand, Carina Ingvast‑Larsson and Lena Olsén at the Department of Biomedicine and Veterinary Public Health, and Department of Clinical Sciences, SLU, conducted the study together with Ulf Bondesson and Mikael Hedeland, Department of Medicinal Chemistry, UU.
Paper in Acta Veterinaria Scandinavica: Cetirizine per os: exposure and antihistamine effect in the dog
Kinetic study of the response to experimentally induced mastitis in cows
An experimental procedure to induce mastitis in cow udders resulted in clinical signs of mastitis and an accumulation of inflammatory mediators and metabolites both in blood plasma and milk. The changes in the milk occurred with a delay as compared to the clinical signs and the effect on the plasma.
The study was led by Gunnar Pejler who is affiliated with Dept. Anatomy, Physiology and Biochemistry at SLU and Dept. Medical Biochemistry and Microbiology, UU. Additional authors at SLU were Carl-Fredrik Johnzon and Ida Waern, Dept. Anatomy, Physiology and Biochemistry; Josef Dahlberg, Dept. Animal Nutrition and Management; Ali A Moazzami, Dept. Molecular Sciences; Karin Östensson, Dept. Clinical Sciences. From UU, Ann-Marie Gustafsson, Dept. Medical Biochemistry and Microbiology, was also part of the research team.
Paper in Frontiers in Immunlogy: The effect of lipopolysaccharide-induced experimental bovine mastitis on clinical parameters, inflammatory markers, and the metabolome: a kinetic approach
Prevalence of interfering antibodies in dogs and cats
In the study, interference – most likely caused by interfering antibodies – was detected in immunoassays of patient samples from dogs and cats. The interference could be neutralized using an immunoassay based on nonmammalian reagents. Eliminating interference in immunoassays is important to avoid misdiagnosis of animals in the clinic.
The study was performed by SLU researchers Daniel Bergman, Helene Hansson-Hamlin, Anna Svensson and Bodil Ström Holst, Dept of Clinical Sciences, in collaboration with Anders Larsson, Department of Medical Sciences, Uppsala University.
Paper in Veterinary Clinical Pathology: Prevalence of interfering antibodies in dogs and cats evaluated using a species-independent assay
Genetic difference correlates with harness racing performance and coat color in horses
Comparisons of genetic patterns in Coldblooded trotters, North-Swedish Draught horses and Standardbreds revealed a gene that can could influence the horses’ racing performance by regulating blood supply. The identified genetic region is potentially also involved in the horses’ coat color.
The research team performing the study were Kim Jäderkvist Fegraeus, Brandon Velie, Jeanette Axelsson and Gabriella Lindgren, Dept. of Animal Breeding and Genetics, SLU, Leif Andersson and Jennifer Meadows, Dept. of Medical Biochemistry and Microbiology, UU, and researchers from University of Sydney, Australia.
Paper in Pysiological Reports: A potential regulatory region near the EDN3 gene may control both harness racing performance and coat color variation in horses
Iron-oxide nanoparticles are toxic and could affect human disease
A whole-blood model was used to evaluate the toxicity of iron-oxide nanoparticles and a noticeable toxicity was observed. This could potentially affect the formation of blood vessels and thereby contribute to cancer, arteriosclerosis and pulmonary disease.
The study was performed by UU researchers Kristina Nilsson Ekdahl, Padideh Davoodpour, Karin Fromell, Osama Hamad and Bo Nilsson, Dept. Immunology, Genetics and Pathology, in collaboration with Gulaim A. Seisenbaeva and Vadim Kessler, Dept Molecular Sciences, SLU. Researchers from Linnaeus University, Umeå University and Swedish Defence Research Agency also participated in the study.
Paper in Nanomedicine: Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles
Diagnostic biomarkers for autoimmune disease in dogs
With an analysis method that is commonly used in humans, autoantibodies against proteins associated with autoimmune disease in dogs were identified. The autoantibodies could potentially be used as biomarkers for diagnosis of SLE-like diseases in both dogs and humans.
SLU and UU researchers in the study were Hanna Bremer, Inger Lilliehöök, Helene Hansson-Hamlin, Dept. Clinical Sciences, SLU, Göran Andersson, Dept. Animal Breeding and Genetics, SLU, Nils Landegren, Maija-Leena Eloranta, Lars Rönnblom, Gunnel Nordmark, Dept. Medical Sciences, UU, and Kerstin Lindblad-Toh, Dept. Medical Biochemistry and Microbiology, UU.
Research news SLU (in Swedish)
Paper in Scientific Reports: ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease