Recent joint publications

June 2018

Kinetic study of the response to experimentally induced mastitis in cows

An experimental procedure to induce mastitis in cow udders resulted in clinical signs of mastitis and an accumulation of inflammatory mediators and metabolites both in blood plasma and milk. The changes in the milk occurred with a delay as compared to the clinical signs and the effect on the plasma.
The study was led by Gunnar Pejler who is affiliated with Dept. Anatomy, Physiology and Biochemistry at SLU and Dept. Medical Biochemistry and Microbiology, UU. Additional authors at SLU were Carl-Fredrik Johnzon and Ida Waern, Dept. Anatomy, Physiology and Biochemistry; Josef Dahlberg, Dept. Animal Nutrition and Management; Ali A Moazzami, Dept. Molecular Sciences; Karin Östensson, Dept. Clinical Sciences. From UU, Ann-Marie Gustafsson, Dept. Medical Biochemistry and Microbiology, was also part of the research team.

More information:
Paper in Frontiers in Immunlogy: The effect of lipopolysaccharide-induced experimental bovine mastitis on clinical parameters, inflammatory markers, and the metabolome: a kinetic approach

June 2018

Prevalence of interfering antibodies in dogs and cats

In the study, interference – most likely caused by interfering antibodies – was detected in immunoassays of patient samples from dogs and cats. The interference could be neutralized using an immunoassay based on nonmammalian reagents. Eliminating interference in immunoassays is important to avoid misdiagnosis of animals in the clinic.
The study was performed by SLU researchers Daniel Bergman, Helene Hansson-Hamlin, Anna Svensson and Bodil Ström Holst, Dept of Clinical Sciences, in collaboration with Anders Larsson, Department of Medical Sciences, Uppsala University.

More information:
Paper in Veterinary Clinical Pathology: Prevalence of interfering antibodies in dogs and cats evaluated using a species-independent assay

May 2018

Genetic difference correlates with harness racing performance and coat color in horses

Comparisons of genetic patterns in Coldblooded trotters, North-Swedish Draught horses and Standardbreds revealed a gene that can could influence the horses’ racing performance by regulating blood supply. The identified genetic region is potentially also involved in the horses’ coat color.
The research team performing the study were Kim Jäderkvist Fegraeus, Brandon Velie, Jeanette Axelsson and Gabriella Lindgren, Dept. of Animal Breeding and Genetics, SLU, Leif Andersson and Jennifer Meadows, Dept. of Medical Biochemistry and Microbiology, UU, and researchers from University of Sydney, Australia.

More information:
Paper in Pysiological Reports: A potential regulatory region near the EDN3 gene may control both harness racing performance and coat color variation in horses

April 2018

Iron-oxide nanoparticles are toxic and could affect human disease

A whole-blood model was used to evaluate the toxicity of iron-oxide nanoparticles and a noticeable toxicity was observed. This could potentially affect the formation of blood vessels and thereby contribute to cancer, arteriosclerosis and pulmonary disease.
The study was performed by UU researchers Kristina Nilsson Ekdahl, Padideh Davoodpour, Karin Fromell, Osama Hamad and Bo Nilsson, Dept. Immunology, Genetics and Pathology, in collaboration with Gulaim A. Seisenbaeva and Vadim Kessler, Dept Molecular Sciences, SLU. Researchers from Linnaeus University, Umeå University and Swedish Defence Research Agency also participated in the study.

More information:
Paper in Nanomedicine: Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles

April 2018

Diagnostic biomarkers for autoimmune disease in dogs

With an analysis method that is commonly used in humans, autoantibodies against proteins associated with autoimmune disease in dogs were identified. The autoantibodies could potentially be used as biomarkers for diagnosis of SLE-like diseases in both dogs and humans.
SLU and UU researchers in the study were Hanna Bremer, Inger Lilliehöök, Helene Hansson-Hamlin, Dept. Clinical Sciences, SLU, Göran Andersson, Dept. Animal Breeding and Genetics, SLU, Nils Landegren, Maija-Leena Eloranta, Lars Rönnblom, Gunnel Nordmark, Dept. Medical Sciences, UU, and Kerstin Lindblad-Toh, Dept. Medical Biochemistry and Microbiology, UU.

More information:
Research news SLU (in Swedish)
Paper in Scientific Reports: ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

March 2018

Nerve toxins discovered in the longest animal on Earth

The research team, led by Ulf Göransson at Uppsala University, found the toxins, which can kill crabs and cockroaches, in the mucus of the bootlace worm, Lineus longissimus. Humans and other mammals appear not to be sensitive to the toxins, which means that they could be developed as insecticides.
Members of the research team were Erik Jacobsson, Camilla Eriksson and Ulf Göransson, Department of Medicinal Chemistry, UU; Henrik Lodén, Mohammadreza Shariatgorji and Per E. Andrén, Department of Pharmaceutical Biosciences, UU; Malin Strand, Swedish Species Information Centre, SLU; and researchers from Linnaeus University, University of Leuven, and University of Queensland.

More information:
Research news Uppsala University (in Swedish)
Paper in Nature: Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

February 2018

New technology for accelerated wound healing

Researchers at Uppsala University and SLU have found a new way of accelerating wound healing. The technology and the mode of action method involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds.
The study was led by Mia Philipson and her group at the Department of Medical Cell Biology, Uppsala University. Collaborator at SLU was Stefan Roos, Department of Molecular Sciences.

More information:
Press release about the paper
Paper in PNAS: Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria