Recent joint publications

April 2018

Diagnostic biomarkers for autoimmune disease in dogs

With an analysis method that is commonly used in humans, autoantibodies against proteins associated with autoimmune disease in dogs were identified. The autoantibodies could potentially be used as biomarkers for diagnosis of SLE-like diseases in both dogs and humans.
SLU and UU researchers in the study were Hanna Bremer, Inger Lilliehöök, Helene Hansson-Hamlin, Dept. Clinical Sciences, SLU, Göran Andersson, Dept. Animal Breeding and Genetics, SLU, Nils Landegren, Maija-Leena, Lars Rönnblom, Gunnel Nordmark, Dept. Medical Sciences, UU, and Kerstin Lindblad-Toh, Dept. Medical Biochemistry and Microbiology, UU.

More information:
Research news SLU (in Swedish)
Paper in Scientific Reports: ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

March 2018

Nerve toxins discovered in the longest animal on Earth

The research team, led by Ulf Göransson at Uppsala University, found the toxins, which can kill crabs and cockroaches, in the mucus of the bootlace worm, Lineus longissimus. Humans and other mammals appear not to be sensitive to the toxins, which means that they could be developed as insecticides.
Members of the research team were Erik Jacobsson, Camilla Eriksson and Ulf Göransson, Department of Medicinal Chemistry, UU; Henrik Lodén, Mohammadreza Shariatgorji and Per E. Andrén, Department of Pharmaceutical Biosciences, UU; Malin Strand, Swedish Species Information Centre, SLU; and researchers from Linnaeus University, University of Leuven, and University of Queensland.

More information:
Research news Uppsala University (in Swedish)
Paper in Nature: Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

February 2018

New technology for accelerated wound healing

Researchers at Uppsala University and SLU have found a new way of accelerating wound healing. The technology and the mode of action method involves using lactic acid bacteria as vectors to produce and deliver a human chemokine on site in the wounds.
The study was led by Mia Philipson and her group at the Department of Medical Cell Biology, Uppsala University. Collaborator at SLU was Stefan Roos, Department of Molecular Sciences.

More information:
Press release about the paper
Paper in PNAS: Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria

January 2018

Visualisation of pancreatic ß-cells

The study shows that targeting the ß-cell protein GRP44 can be used to image pancreatic ß-cells in vivo using PET. 
Participating researchers at UU were Olof Eriksson, Dept. of Medicinal Chemistry, and Olle Korsgren, Dept. of Immunology, Genetics and Pathology, and at SLU Marianne Jensen-Waern, Dept. of Clinical Sciences.

Paper in Diabetes: In vivo visualization of β-cells by targeting of GPR44

December 2017

Genetic analysis of Iclandic horses' ability to pace

Iclandic horses with an ability to perform the two gaits tölt and pace were genetically compared with Iclandic horses that could not pace. No single gene variants were found to be linked with the ability to pace.
The study was performed by SLU researchers Kim Jäderkvist Fegraeus, Insa Hirschberg, Brandon Velie and Gabriella Lindgren at the Dept. of Animal Breeding and Genetics, together with Leif Andersson, Dept. of Medical Biochemistry and Microbiology, UU.

More information:
Web news
Paper in Animal Genetics: To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation

November 2017

Dog ownership linked to lower mortality

A team of Swedish scientists have used national registries of more than 3.4 million Swedes aged 40 to 80 to study the association between dog ownership and cardiovascular health. Their study shows that dog owners had a lower risk of death due to cardiovascular disease or to other causes during the 12-year follow-up.
The study was led by Tove Fall and her team at the Dept. Medical Sciences, UU. Collaborator at SLU was Agneta Egenvall, Dept. Clinical Sciences.

More information:
Press release about the publication
Paper in Scientific Reports: Dog ownership and the risk of cardiovascular disease and death - a nationwide cohort study

November 2017

Less scars and discolored skin when burn damages are healed with a new titanium-based nanomaterial

A material based on titanium dioxide nanoparticles has proven to be very promising in the treatment of burned skin. Particularly valuable is that it appears to reduce the formation of scar tissue and discolored skin.
The study was led by Vadim Kessler together with Gulaim A. Seisenbaeva at the Dept Molecular Sciences, SLU. Collaborators at UU were Karin Fromell, Bo Nilsson and Kristina Nilsson Ekdahl, Dept. Immunology, Genetics and Pathology.

More information:
Press release about the publication
Paper in Scientific Reports: Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins